Prisoners in the Dekel Prison in Be'er Sheva on Monday night lit a number of mattresses and sheets on fire in one of the cells, Kikar Hashabbat reported.
Prison staff began working to extinguish the fire and within a few minutes had gained control of the flames. At the same time, staff worked to evacuate the prisoners from the cell.
Five prisoners were taken to Soroka Medical Center for medical treatment. One prisoner was hospitalized but is not in danger, and the others were returned to the prison.
A fire investigator has been called to the prison, along with a police detective. All of those involved in the incident will face both disciplinary measures and criminal investigations.
"As in this incident, the Prisons Service staff works constantly with professionalism and responsibly to ensure the safety of the prison facilities and to protect the lvies and welfare of the prisoners held in them," the Prisons Service said.