US President Joe Biden departed from Andrews Air Force Base on Tuesday night, as he makes his way to Israel.

Biden is expected to land in Israel at 3:30 p.m. and begin his first diplomatic visit to the region since taking office.

At 3:45 p.m., the President will be received at an official reception at Ben-Gurion Airport with the participation of President Isaac Herzog, Prime Minister Yair Lapid, and Alternate Prime Minister Naftali Bennett.

At 4:15 p.m., Biden will tour the Defense Ministry's multi-tiered air defense system accompanied by Prime Minister Lapid and Defense Minister Benny Gantz. The Defense Minister will also provide Biden with an overview of bilateral security cooperation. At 5:35 p.m., Biden will pay a visit to the Yad Vashem Holocaust Remembrance Museum.

Biden will remain in Israel until Friday, when he will depart for Saudi Arabia for the second leg of his Middle East tour.

Traffic jams and roadblocks are expected throughout Biden’s visit, starting on Wednesday afternoon and until Friday afternoon. These disruptions will be felt in central Israel, on the roads leading to Jerusalem and throughout the city of Jerusalem itself. There may also be changes in traffic arrangements on the main routes leading to the city for short periods of time.

During the days of the visit, more than 16,000 police officers, Border Police officers and volunteers will be deployed to maintain public order and direct traffic.