Israel's Health Ministry on Tuesday morning reported a suspected cyber incident at the Kfar Shaul Eitanim hospital.
The Jerusalem mental health hospital has now moved to manual management.
"Medical teams continue to treat the patients, and parallel to this, the incident is being investigated by the Health Ministry's cyber staff and the National Cyber Directorate," the Ministry said.
Last month, a cyber attack on Mayanei Hayeshua Medical Center caused the hospital's computer systems to fail, but did not affect medical equipment.
The hospital was cleared of ransomware on the same day, about 12 hours later.