At least 21 people were killed and dozens more injured when a bus fell off of a bridge a few miles from Venice, Italy, this evening (Tuesday).

Video from the scene shows rescue workers surrounding the overturned and crushed bus, working to extract passengers from the vehicle. Smoke could also be seen rising from the bus, which landed right next to railroad tracks.

Forty ambulances were summoned to care for the victims and transport them to the hospitals.

Venice Mayor Luigi Brugnaro told local media: "A huge tragedy struck our community this evening. I immediately declared the city to be in mourning, in memory of the numerous victims who were on the fallen bus.

The mayor called the scene "apocalyptic" and said that "there are no words to describe it."

Israel's Foreign Ministry is investigating if any Israeli citizens were on the bus at the time of the accident.