Prime Minister Netanyahu's wife Sara was charged on Thursday with fraud and breach of trust after a long police probe into allegations she falsified household expenses, the justice ministry said.
"The Jerusalem district prosecutor a short time ago filed charges against the prime minister's wife," the ministry said.
The allegations announced last year are that she and an aide falsely declared there were no cooks available at the prime minister's official residence and ordered from outside caterers at public expense.
The cost amounted to "over 350,000 shekels ($97,000))", the justice ministry said.
She has denied any wrongdoing.
Her husband is himself under investigation on suspicion of corruption offenses.
In one case, he and family members are suspected of receiving one million shekels ($285,000, 240,000 euros) worth of luxury cigars, champagne and jewelry from wealthy personalities in exchange for financial or personal favors.
In the other case, investigators suspect the premier of trying to reach an agreement with the owner of Yediot Aharonot for more favorable coverage.
Netanyahu has protested his innocence and vowed to remain in power, saying
he is the victim of a "witch-hunt".
He also faces suspicions of government favors that allegedly saw regulatory breaks go to Israel's largest telecom firm Bezeq, in return for favorable coverage of him and his wife by a news website.
Despite his troubles, opinion polls suggest Netanyahu's Likud party would remain the largest in the Knesset if elections scheduled for November 2019 were held now.