A Palestinian man was shot dead on Tuesday during clashes with the Israeli army in Hevron, as Israeli security forces seek to crack down on escalating Arab violence.
Imad Jawabreh, 22, died after being hit in the chest by bullets, medics said following the incident which took place on Route 60 near to the Jewish town of Kiryat Arba.
The Israeli army confirmed troops had opened fire at rioters who were stoning cars in the area.
"Around 150 Palestinians gathered on the main road near Hebron hurling rocks and Molotov cocktails at passing vehicles," a spokeswoman said.
She said troops used riot dispersal means to try to break up the disturbances, eventually firing at the rioters' lower bodies, hitting one of them.
Israel stepped up security nationwide Tuesday after a soldier and a 26-year-old woman were killed in separate Palestinian knife attacks, as months of unrest in Jerusalem spread across the country.
Thousands of police deployed at potential flashpoints as Palestinians held low key ceremonies to mark 10 years since the death of PLO terror chief Yasser Arafat in a hospital near Paris.
On Monday a 17-year-old Palestinian terrorist in Tel Aviv stabbed a 20-year-old soldier who later died of his wounds in hospital. The assailant fled but was arrested.
Hours later, in the Gush Etzion region south of Jerusalem, another Islamist terrorist ran over three Israeli civilians before stabbing one of his injured victims to death. 26-year-old Dalia Lemkos was murdered in that attack, and another two people were wounded.
The bloodshed followed months of clashes between Israeli security forces and Arab rioters hurling rocks and firebombs in Jerusalem.
The unrest spread to the Galilee in northern Israel at the weekend after police shot dead a knife-wielding Arab-Israeli during a routine arrest operation.
With the public increasingly on edge, the Israeli government has boosted security measures.
"The police have been placed on an advanced state of alert. Thousands of police, officers, volunteers and reinforcements have been deployed across the country to ensure the security of the public," police spokeswoman Luba Samri told AFP.
Following the Tel Aviv attack - carried out by an illegal Palestinian worker - police began a nationwide crackdown on illegals, she said.
The authorities urged the public to "be vigilant" and report "any suspicious vehicle or individual."
The growing sense of fear on the streets has evoked memories of the second deadly Palestinian intifada, or terror campaign, which began in 2000.
Arrests in the Negev; 'Price tag' in Jerusalem
Overnight, police arrested five people in the southern Bedouin town of Hura for throwing stones at a police car, and found one of them - a woman - to be carrying an M16 assault rifle.
Meanwhile in Jerusalem at least five cars in the predominantly Arab neighborhood of Beit Safafa had their tires slashed and anti-Arab graffiti was sprayed nearby, in an apparent 'price tag' revenge attack by Jewish youths. Elsewhere in the capital, police arrested four Jewish minors for throwing stones at an Arab-owned taxi for "nationalist motives."
The Israeli army also confirmed deploying reinforcements throughout Judea and Samaria.
Israel has significantly increased the police presence on the streets in recent months in a bid to rein in the unrest, but has been unable to stop a growing number of attacks by lone-wolf terrorists, most of them in Jerusalem.
But Monday's violence was further afield, reaching Tel Aviv and the Gush Etzion region to the south of the capital, in a move condemned by Washington and Brussels.
"It is absolutely critical that the parties take every possible measure to protect civilians and de-escalate tensions," said US State Department spokeswoman Jen Psaki.
Since August, Jerusalem has seen four Palestinian attacks - three "hit-and-run terror attacks" which killed five Israelis and one attempted drive-by shooting.
All four perpetrators, who acted alone and came from east Jerusalem, were shot dead, sparking further unrest.
Since July, Jerusalem police have arrested some 900 Arab extremists for public order offences and indicted around a third of them.
AFP contributed to this report.