Israeli Prime Minister Binyamin Netanyahu was among world leaders who sent their condolences to US President Barack Obama following the deadly shooting spree at an Orlando, Florida gay nightclub.
Netanyahu joined the chorus of international condemnation of the attack - believed to have been an act of Islamic terrorism - which left 50 people dead and more than 50 others wounded.
"In the name of the government of Israel and the citizens of Israel I send our sincere condolences to the American people following the criminal attack on the LGBT community last night in Orlando," he said in a statement issued in Hebrew.
"Israel stands shoulder to shoulder alongside the United States at this moment of tragic loss," Netanyahu added. "We send our heartfelt sympathies to the families of the victims and wish a full and speedy recovery to the wounded."
Netanyahu's condemnation came just days after Islamist Hamas terrorists went on a shooting spree in central Tel Aviv, killing four people and wounding several others at the popular Sarona Market before being apprehended.
Other world leaders also rushed to condemn the Orlando attack, which was carried out by Muslim-American Omar Mateen, who according to reports pledged allegiance to the ISIS terrorist group shortly before carrying out the massacre.
French President Francois Hollande condemned "with horror" the slaughter, and underlined that the "full support of France and the French (is) with America's authorities and its people in this difficult time."
Pope Francis similarly condemned the "homicidal folly" with "deep horror and condemnation," in a statement from the Vatican.
The attack was the worse gun massacre in American history.