Muslim Brotherhood leader Mohammed Badie and 36 other supporters of ousted Egyptian President Mohammed Morsi got life sentences Saturday in Cairo, CNN reported.
The defendants are accused of inciting violence.
An additional 10 defendants sentenced to death in June have had their sentences upheld by Egypt's Grand Mufti, who, by law, must review capital punishment decisions.
This is the second sentence handed down to Badie, who was found guilty and sentenced to death in April. He was also given a second death sentence in late June over violence that killed 10 people in Cairo last summer.
Since the army ousted Islamist president Mohammed Morsi in July of 2013, hundreds of his supporters and Badie himself have been sentenced to death in speedy mass trials that have sparked international outrage.
Since Morsi's ouster, his supporters have staged regular protests calling for his reinstatement, rallies that have often degenerated into street clashes with security forces and civilian opponents.
A crackdown on Morsi supporters has left more than 1,400 people dead in street clashes and at least 15,000 jailed.
Badie has in the past called for a jihad (holy war) to liberate Jerusalem from Israeli rule. A recently released video of him shows him telling the court that his movement was not against Egypt but only against the Jews.