Enraged Muslims in the Sudanese capital Khartoum stormed the German embassy there, setting it partially on fire and raising an Islamist banner. The British embassy was also attacked, according to the BBC. The German foreign ministry confirmed all its staff in Khartoum were safe.
One person was killed in Lebanon, and five were hurt in Cairo. There were also clashes in Yemen, Tunisia, Iraq and Jerusalem.
Iraqi protesters burned US and Israeli flags as thousands of people demonstrated for a second day Friday in cities and towns across Iraq against an anti-Islam film that has sparked outrage in the Muslim world.
the biggest protest, thousands of people turned out in the southern port city of Basra, carrying Iraqi flags and shouting slogans including: "There is no freedom [of] abusing the feelings of two billion Muslims."
The protesters burned American and Israeli flags, an AFP correspondent said.
In Cairo, police fired tear gas at about 500 protesters, pushing them back from the US embassy. The streets nearby have been blocked with barbed wire, concrete and police vehicles.
In Lebanon, rioters in Tripoli set fire to a KFC branch. Pope Benedict XVI was set to visit the country for the fourth time on Friday.
In Jerusalem, demonstrations were held after Friday prayers at the Al-Aqsa mosque in the Old City.
The protests began peacefully with several hundred people demonstrating on the plaza that holds both the Al-Aqsa and Dome of the Rock mosques, chanting, "With our blood and our soul, we will sacrifice for you our Prophet."
But clashes broke out between a part of the crowd and Israeli police as the demonstration moved out of the Old City, with security forces firing tear gas and stun grenades that injured at least five people, an AFP correspondent said. Several policemen were reportedly hurt.
"Israel police are dispersing rioters at Damascus Gate, rocks and stones are being thrown at them," police spokesman Micky Rosenfeld told AFP in the early afternoon.
Demonstrators appeared to be trying to head to U.S. diplomatic premises in east Jerusalem, with Israeli police, some on horseback, seeking to prevent the protest from moving.
There was also some Arab rioting in Akko, in northern Israel.
In Gaza, thousands of people rallied at demonstrations in Gaza City and the southern town of Rafah, a day after the ruling Hamas party urged citizens to turn out for protests after Friday prayers.
Protesters waved the flags of the Hamas and Islamic Jihad movements, and set fire to American flags, chanting "Death, death to America, death, death to Israel."
Hamas prime minister Ismail Haniyeh, in a sermon during Friday prayers, repeated a call on Washington to apologize for a film, produced in the United States, which portrays Islam's Mohammed in a negative way.
"The US administration should apologize to the Arab and Islamic nation for this offensive film and bring these criminals to justice," he said.
Haniyeh said the film was the result of "a Jewish-American-Crusader alliance to ignite a war on Islam and sectarian strife, particularly in Egypt."
The amateur production called "Innocence of Muslims," which was virtually unheard of before this week, has sparked violent protests across the Middle East.
The U.S. ambassador to Libya and three other US personnel were killed in a terror attack at the city of Benghazi, and four people were killed on Thursday when Yemeni police opened fire at a protest in Sana'a.