US Secretary of State John Kerry on Monday said he hoped for "clarity" within 48 hours on the parameters of peace talks aimed at ending Syria's five-year war, AFP reports.

Speaking in Laos, America's top diplomat said he has held a flurry of conversations with key parties including his French, Turkish, Russian and Saudi counterparts.

He has also spoken with UN special envoy to Syria, Staffan de Mistura "to make sure everybody is on the same page" ahead of the talks, which had been slated to begin on Monday but now appear in doubt.

"We are gonna have the meeting and they (the talks) are gonna start, we will have clarity I hope within 24 hours, somewhere like that, 48, something pretty soon," Kerry told reporters during a trip to Laos.

"We are talking about the modalities of the ceasefire, we are talking about the modalities of humanitarian or other confidence-building measures," he said, adding he felt "positive" over the negotiations.