At least four people have been shot outside the Empire State Building, according to New York police.
A fire department spokesman says it received a call about the shooting just after 9am local time (13:00 GMT) on Friday and that emergency units were on the scene within minutes.
The incident does not appear to be terror-related, police said. Police have closed several streets around 5th Avenue and 34th Street in Manhattan.
The Empire State Building is one of the most famous skyscrapers in the world, and one of New York City's best-known tourist attractions.