Iranian supreme leader Ayatollah Ali Khamenei warned commanders of the elite Revolutionary Guards Wednesday to be on alert for "political and cultural" infiltration by the United States, AFP reports.

"The main purpose of the enemies is for Iranians to give up on their revolutionary mentality," Khamenei told a gathering of Guards commanders and personnel in Tehran.

"Enemy means global arrogance, the ultimate symbol of which is the United States," he said, calling on the powerful branch of the military to protect the revolution.