Education Minister Naftali Bennett (Jewish Home) congratulated US President Donald Trump on his inauguration and move to the White House.
"We've entered a new era," Bennett wrote on Twitter. "For the first time in fifty years, our Prime Minister has a choice whether to create a Palestinian state or to apply israeli sovereignty in Judea and Samaria.
"If we choose to create a Palestinian state, we will regret our choice for generations to come. We will work to apply Israeli sovereignty."
Responding to Israeli Prime Minister Binyamin Netanyahu's Facebook post, in which Netanyahu said Iranian civilians are our friends, Bennett said, "Iran is an important topic, but preventing a second Iran in the heart of Judea and Samaria is no less important.
"We must not allow the 'Iran threat' to be used an excuse to miss an historical opportunity to prevent Palestine from developing on Israel's Route 6."
Route 6 is one of Israel's main north-south highways, crossing much of the country.
"I will fight for you with every breath in my body - and I will never, ever let you down," Trump said in his inauguration speech. "We will seek friendship and goodwill with the nations of the world - but we do so with the understanding that it is the right of all nations to put their own interests first.
"We do not seek to impose our way of life on anyone, but rather to let it shine as an example for everyone to follow.
"We will reinforce old alliances and form new ones - and unite the civilized world against radical Islamic terrorism, which we will eradicate completely from the face of the Earth," he promised.