Israeli aircraft on Friday night attacked several targets near the Damascus airfield, Syrian media reported.
The attack seems to have been directed at weapons storehouses belonging to Hezbollah and Syrian President Bashar al-Assad's army.
Syrian websites published pictures of fires which were claimed to be the result of the attack.
An IDF spokesperson said he would "not respond" to the reports.
On September 7, the Syrian army claimed Israeli warplanes had attacked a military base in western Syria. According to the announcement, two soldiers were killed in the strikes and part of the base was destroyed.
The IDF did not confirm responsibility for the attack.