For first time in 40 years, cure for acute leukemia within reach

Hebrew University drug trials show 50% cure rate in lab mice.

Ohad Tobi,

Cancer research (illustrative)
Cancer research (illustrative)
Flash90

Acute myeloid leukemia is one of the most aggressive cancers. While other cancers have benefited from new treatments, there has been no encouraging news for most leukemia patients for the past 40 years. Until now.

According to an article published Friday in the scientific journal Cell, Professor Yinon Ben-Neriah and his research team at the Hebrew University of Jerusalem (HU)’s Faculty of Medicine have developed a new biological drug with a cure rate of 50% for lab mice with acute leukemia.

Leukemia produce a variety (and a high quantity) of proteins which together provide leukemic cells with rapid growth and death protection from chemotherapy.

To date, most of the biological cancer drugs used to treat leukemia target only individual leukemic cell proteins. However, during “targeted therapy” treatments, leukemic cells quickly activate their other proteins to block the drug. The result is drug-resistant leukemic cells which quickly regrow and renew the disease.

However, the new drug developed by Ben-Neriah and his team functions like a cluster bomb. It attacks several leukemic proteins at once, making it difficult for the leukemia cells to activate other proteins that can evade the therapy. Further, this single molecule drug accomplishes the work of three or four separate drugs, reducing cancer patients’ exposure to therapies and the necessity of dealing with their often unbearable side effects.

Additionally promising is the new drug’s ability to eradicate leukemia stem cells. This has long been the big challenge in cancer therapy and is one of the main reasons that scientists have been unable to cure acute leukemia.

“We were thrilled to see such a dramatic change even after only a single dose of the new drug. Nearly all of the lab mice’s leukemia signs disappeared overnight,” shared professor Ben-Neriah.

BioTheryX recently bought the rights to this promising drug from HU’s technology transfer company Yissum. Together with Ben-Neriah’s research team, they are now applying for FDA approval for Phase I clinical studies.


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