Egypt has cut diplomatic ties with Damascus and has ordered the Syria's embassy in Cairo to be closed, the Egyptian president says.
President Mohammed Morsi also urged world powers to enforce a no-fly zone over Syria.
He also called on Lebanon's Hizbullah to leave Syria, where the Iranian proxy militia has been fighting alongside troops loyal to President Bashar al Assad.
The Islamist president was speaking to thousands of supporters in a Cairo stadium, in a rally titled "Support for Syria."
Egypt "decided today to definitively break off relations with the current regime in Syria, to close that regime's embassy in Cairo and to recall Egypt's charge d'affaires" from Damascus, he said.
Egypt sides with the islamist rebels who are trying to topple Assad.
Meanwhile, Israeli and U.S. military officials are coordinating how to target and destroy Syrian president Bashar Assad’s arsenal of unconventional weapons under assorted scenarios, Israeli military and intelligence officials toldTIME Magazine.